Microstructured optical fiber Bragg grating sensor for DNA detection

Candiani, A., Sozzi, M., Coscelli, E., Cucinotta, A., Bertucci, A., Corradini, R., Konstantaki, M., Margulis, W., Pissadakis, S., Selleri, S., and Giannetti, S.
Type of publication: 
Conference item

The realization of a DNA biosensor based on a microstructured optical fiber (MOF) Bragg grating has been demonstrated. The microchannels surface of the MOF has been functionalized with peptide nucleic acid (PNA) in order to capture DNA strands, and then oligonucleotide-functionalized gold nanoparticles (ON-AuNPs) were used to achieve signal amplification. Wavelength shift of the high order mode in the reflected spectra, due to the PNA - DNA and DNA - ON-AuNPs bindings, proved the occurred fiber hybridization. The re-use of the fiber for multiple measurements and the selectivity of the sensor have been demonstrated.

The Moscone Center San Fransisco
United States
Published in: 
SPIE Photonics West, BIOS, Proceedings of SPIE Volume 8576. San Fransisco, USA. February 2013.