Screen printed ion pumps

ProjectOrganic BiOElectronics

Key Areas
Competence Areas at RISE ICT
Organic BiOElectronics

Acreo Swedish ICT AB is taking part in the OBOE center, which is funded by the Swedish Foundation for Strategic Research (SSF) and Vinnova. The OBOE center includes researchers and engineers from Linköping University, Karolinska Institute and Acreo Swedish ICT AB. The center director is Professor Magnus Berggren at Linköping University. Linköping University and Acreo Swedish ICT AB have a large competence in the field of organic electronics and the materials used in the field. Karolinska Institute is a leading expertise in the field of cell and molecular biology, neurobiology and stem cell research. The goal is to combine these research fields and develop an organic bioelectronics platform of tools that offers biologists to answer some long standing questions in biology related to cell-signalling, stem cells and neural interconnects. The three research areas of OBOE is

  • Stem cells: electronic control of cell attachment, differentiation and release events, to understand and regulate cell differentiation.
  • Intracellular signalling: coupling between in vivo sensing, signal processing and electronic/electrochemical launching of signal substances (e.g. hormones, ions).
  • Neural interconnects: organic electrodes and amplification transistors, which use chemical and electronic signal carriers to communicate with individual and networks of neural cells.

Acreo Swedish ICT AB is working on finding manufacturing routes for the bioelectronic devices included in the OBOE center. The devices we currently are focusing on are the OBOETTE, screen printed flat ion pumps and the e-release device, see the figures. The ion pump offers a unique possibility to translate electronic signalling into chemical messengers such as ions or neurotransmitters upon applying an electric potential across the device. These devices provide several sought-after features for regulation of cell signalling: exact dosage determination through electrochemical relationships, minimally disruptive delivery due to lack of fluid flow, and on–off switching. This technology has great potential as a therapeutic platform and could help accelerate the development of therapeutic strategies for nervous-system disorders. When the ion pumps have been characterised they can be distributed to scientists that need spatially and temporally controlled transport of ions/charged molecules.

The OBOETTE ion pump

In cell biology, there is a need to detach the cells from the surface after cultivation. There are different methods to achieve this, one uses chemistry and the other temperature. Drawbacks with these methods are the change in cultivating temperature and that extracellular matrix protein is damaged. The benefit with the e-release device is that it is chemical free and can be applied at normal temperature for culturing. The detachment is performed by applying a small potential, typically 1V.

Acreo Swedish ICT AB and the OBOE center are currently looking for both commercial and research collaborations.

External homepage: 
http://www.oboecenter.se/