Biomonitoring for diabetes research

Acreo Swedish ICT and Biocrine collaborate in the development of a technology for better understanding of diabetes.

Biocrine has developed the InSight technology that makes it possible to study insulin-producing beta cells within the living animal non-invasively, longitudinally and at single cell resolution. Normally these cells are located in the endocrine  pancreas, a site that is not readily accessible for fluorescence microscopy. With InSight technology this problem is overcome by detection of fluorescence from biosensors within beta cells transplanted to the anterior chamber of the eye, where the cornea serves as a natural body window for non-invasive optical detection. In this setting the beta cells display the function they normally have in situ in the pancreas.

Acreo and Biocrine in collaboration now develop the next generation of this exciting sensing technology. The goal is to complement the fluorescence microscopes used today with a miniaturized detection system integrating excitation light sources, detection units and data communication components. With a miniaturized system it will be possible to perform the measurements on conscious animals, which provides a more natural condition to monitor unperturbed beta cell function in the living organism.

Acreo Swedish ICT and Biocrine have started a project where the first steps are taken towards a realization of this vision.

 

Figure reproduced from Abdulreda MH et.al.  J Vis Exp. 2013 Mar 10;(73)

Collaborating partners

Biocrine