Bio Analysis

Miniaturisation of biomedical tools with integrated lab-on-chip solutions speed up the analysis and reduces the sample volume. We have expertise in microfluidic solutions and integrated sensor technologies. Most applications are related to cell culturing and diagnostics.

We offer

• Microfluidic solutions
• Integrated sensors
• Chip manufacturing

Project references

Microfluidics for electrical nanowire biosensor - KTH, UU, Vinnova NanoWire

Microfluidic cell culture chamber for drug screening - KI, EU FP7 EUROHEAR

Electrochemical luminescence in microfluidic cell - KI, SU, Vinnova NanoECL

Electrospray ionization for mass spectrometry - KTH, SSF Nanokemi

Flow sensor study - Artema

Microfluidic measurement setup for nanosensor - Midorion

Microfluidic silica chip fabrication - Gnothis

Single molecule detection in microfluidic channels - KI,Vinnova Kofuma

Lab-on-CD micro replication technology - Gyros, Vinnova Summit, SSF BRO

Micro drop dispenser - Gyros

Micro-valve - Pharmacia Biotech

Multisensor - Pharmacia Biotech

Micro-calorimeter - Pharmacia Biotech

Publication Selection

1. A two-terminal silicon nanoribbon field-effect pH sensor,
   Chen S., Jokilaakso N., Björk P., Eriksson Karlström A., Zhang S.-L.,
   Appl. Phys. Lett. 97, 264102 (2010).
2. Miniaturized in vitro cell culture devices for organized culturing of inner ear neural cells.
   P. Bjork, B. Kostyszyn, T. Schonberg, M. Hakanson, M. Ulfendahl and C. Vieider.
   13th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (µTAS2009), ICC Jeju, Korea, Nov (2009).
3. Electrospray ionization from an adjustable gap between two silicon chips.
   P. Ek, T. Schönberg, J. Sjödahl, J. Jacksén, C. Vieider, Å. Emmer, J. Roeraade. Journal of Mass Spectrometry, Oct (2008).
4. Surface protein patterns govern morphology, proliferation, and expression of cellular markers but have no effect on physiological properties of cortical precursor cells
   A K. Magnusson, P Linderholm, C Vieider, M Ulfendahl, A Erlandsson. Journal of Neuroscience Research 86 (11), Aug 2008
5. Ultrasensitive microfluidic cell for detecting small biomolecules using electrochemi­luminescence.
   T. Schönberg, M. Ahrne, J. Kehr, C. Vieider. 22nd Int. Symp. On Microscale Bioseparations and Methods for System Biology (MSB2008), Berlin, Germany (2008).
6. Realisation of picoliter flow switching in microstructures using commercially available valves
   Henriksson, P., Blom, H., Gösch, M., Hedman, A.-S., Arvidsson, G., Vieider, C., and Rigler, R., Micro Total Analysis Systems 2003, Proceedings p 519, 2003
7. Electroosmosis- and Pressure-Driven Chromatography in Chips Using Continuous Beds
   C Ericson, J Holm, T Ericson, S Hjertén, Anal. Chem. 72, pp 81–87, 2000
8. Detection and selection of single biomolecules with hydrodynamic flow in microstructures M Gösch, H Blom, P Thyberg, Z Földes-Papp, G Björk, J Holm, T Heino, R Rigler, Journal Bioscience. 24 (Suppl. 1), 191, 1999
9. A chemical micro analysis system for measurement of pressure, flowrate, temperature, conductivity, UV-absorption and fluorescence
   Norlin, P.   Ohman, O.   Ekstrom, B.   Forssen, Sensors and Actuators B 49 (1998) 34
10. Silicon Based Replication Technology of 3D-Microstructures by Conventional CD-Injection Molding Techniques,
    O Larsson, O Öhman, Å Billman, L Lundbladh, C Lindell and G Palmskog, 9th Intern Conf on Solid-State Sensors and Actutators (Transducers ´97), 1997, Proc. 1415-1418
11. Refractive index measurements using integrated ring reso­nators,
    Sohlström H, Öberg M, Proc. ECIO’97, Stockholm (1997).
12. Pneumatically actuated micro valve with a silicone rubber membrane for integration with fluid-handling systems
    C Vieider, O Ohman, H Elderstig, International Conference on Solid-State Sensors and Actuators, Proceedings,  v 2, 1995, p 284-286